High cholesterol raises Alzheimer’s risk
People with high cholesterol levels may have an increased risk of developing Alzheimer’s, according to a study by Japanese researchers and published in the medical journal Neurology
“We found that high cholesterol levels are significantly associated with senile plaques associated with Alzheimer’s disease,” said Dr. Kensuke Sasaki of Kyushu University in Fukuoka.
The study examined 147 people who died after a prolonged observation period Alzheimer (10 to 15 years), of which 50, 34% had been diagnosed with the disease before death.
The researchers looked for signs of senile plaques, amyloid protein accumulation between nerve cells, and neurofibrillary tangles, accumulation of other types of protein inside nerve cells, both considered by experts as the two main signs of Alzheimer’s.
From the sample taken, people with high cholesterol levels, ie more than 224 milligrams per deciliter, recorded significantly more senile plaques than those with low or normal levels of cholesterol.
A total of 86% of people with high cholesterol levels had these senile plaques, compared with only 62% with low levels.
However, researchers have found a link about the other signs of Alzheimer’s neurofibrillary tangles.
Sasaki also revealed that preliminary tests had shown that insulin resistance, a sign of diabetes, may be another risk factor for senile plaques associated with this disease.
Our research clearly marks that high cholesterol can contribute directly or indirectly to these senile plaques,” said the researcher Nippon.
However, he explained that “the negative trials of treatment with drugs that reduce cholesterol in patients with Alzheimer’s disease show no simple connection between lower cholesterol and prevent disease.”